CALL FOR PAPERS Sex and Gender Differences in Pain and Inflammation NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice
نویسندگان
چکیده
Camron D. Bryant, Shoshana Eitan, Kevin Sinchak, Michael S. Fanselow, and Christopher J. Evans Interdepartmental Program in Neuroscience and Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles (UCLA), Los Angeles, California; Department of Psychology, Texas A&M University, College Station, Texas; Department of Psychology, Center for Neuroendocrine Studies, Neuroscience and Behavior Laboratory, University of Massachusetts, Amherst, Amherst, Massachusetts; and Department of Psychology, UCLA, Los Angeles, California
منابع مشابه
NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice.
Multiple studies demonstrate that coadministration of N-methyl-D-aspartate (NMDA) receptor antagonists with the opioid agonist morphine attenuates the development of analgesic tolerance. Sex differences in the effects of noncompetitive, but not competitive NMDA receptor antagonists on acute morphine analgesia, have been reported in mice, yet the role of sex in modulation of morphine tolerance b...
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Introduction: Morphine is a potent analgesic but its continual use results in analgesic tolerance. Mechanisms of this tolerance remain to be clarified. However, changes in the functions of μ-opioid and N-Methyl-D-aspartate (NMDA) receptors have been proposed in morphine tolerance. We examined changes in gene expression of the NMDA receptor subunit 1 (NR1) at mRNA levels i...
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Various physiological parameters including level of sex steroids undergo alterations following chronic administration of morphine. In this study, the effect of chronic administration of morphine on phasic and tonic pain was studied in morphine-dependent male and female rats in the presence and absence of gonads using formalin test. In addition, for evaluation of differences in dependency, withd...
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